%���� Dose Conversion Table for Statins. endobj May 2012 (full update Nov 2013). 3 0 obj The 80 mg dose should be considered only in patients with severe hypercholesterolaemia and high risk of cardiovascular complications who have not achieved their treatment goals on lower doses, when the benefits are expected to outweigh the potential risks. 2 0 obj <> Last updated: This grouping was agreed by GDG consensus, informed … <> 18 July 2014 x��=ے�6���?�Qܲ8A�r��'�w�=���I�qBQ��|�Aw$@�f2'�L$ Published date: STATIN CONVERSION CHART % LDL Reduction Simvastatin (Zocor) Atorvastatin (Lipitor) Rosuvastatin (Crestor) Fluvastatin (Lescol) Lovastatin (Mevacor) Pravastatin (Pravachol) Ezetimibe/Simvastatin (Vytorin) <24% 5 mg - - 20 mg 10 mg 10 mg - 25-32% 10 mg - - 40 mg 20 mg 20 mg - 31-39% 20 mg 10 mg - 80 mg 40 mg 40 mg - 37-45% 40 mg 20 mg 5 mg - 80 mg 80 mg 10/10 See the full guideline for a discussion of this grouping. Finding more information and committee details. <>>> For the purpose of this guideline, statins are grouped into 3 different intensity categories according to the percentage reduction in low density lipoprotein cholesterol: a 20% to 30% reduction is low intensity. This information is from Law MR, Wald NJ, Rudnicka AR (2003) Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta‑analysis. a 31% to 40% reduction is medium intensity. MHRA advice: there is an increased risk of myopathy associated with high dose (80 mg) simvastatin. BMJ 326: 1423. 1 0 obj When choosing a statin dose, expected LDL reduction is not the only factor to consider. %PDF-1.5 Pharmacist’s Letter/Prescriber’s Letter. <>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 24 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> This grouping was agreed by GDG consensus, informed by analyses in the literature. �F��7���vw]�Z���ū�-W�j�~��\��q���]u����e�����~x}�~�����O�����g�E�_Τ��HX&�0J�����"��?o�?�m��?��>����~|�.���q�iqVST-H�� zNS'a�u93D����D�E3��P 1�d+5����rS�u�~�[$�@U��B�%�j)���4fM����?�?��~�9[faqj�`J�.����. endobj Statin Dose Comparison The chart below shows statin doses expected to provide similar LDL reduction. Dosage adjustment may be needed based on renal function, race, or drug interactions. Guidance on Prescribing Statins Please also refer to South London Algorithm for Lipid Management for the Primary and Secondary Prevention of cardiovascular disease (CVD) www.swlmcg.nhs.uk The following issues need to be considered when prescribing a statin: Have an informed discussion with the patient about the benefits and risks of statin treatment. endobj Appendix A: Grouping of statins. Clinical guideline [CG181] For the purpose of this guideline, statins are grouped into 3 different intensity categories according to the percentage reduction in low density lipoprotein cholesterol: a 31% to 40% reduction is medium intensity. 280502. a reduction of more than 40% is high intensity. 4 0 obj a reduction of more than 40% is high intensity. 3 Characteristics of Various Statins. 27 September 2016. stream LOVASTATIN PRAVASTATIN SIMVASTATIN % LDL Reduction(MEVACOR*) (PRAVACHOL*) (ZOCOR*)LESCOL LIPITOR CRESTOR VYTORIN 25-32% 20 MG 20MG 10MG 40MG - - - 31-39% 40MG 40MG 20MG 80MG 10MG - - 37-45% 80MG 80MG 40MG - 20MG 5MG 10/10 48-52% - - 80MG - 40MG 10MG 10/20 55-60% - - - - 80MG 20MG 10/40 60-63% - - - - - 40MG …